CAE (Caprine Arthritis-encephalitis Virus) and OPPV (Ovine Progressive Pneumonia Virus) are persistent lentivirus infections of goats and sheep, respectively. Molecular analysis Molecular analysis indicates that CAE virus (CAEV) and OPP virus (OPPV) are very similar and they are often grouped together under the name small ruminant lentivirus (SRLV). Polyarthritis is the main clinical sign of CAEV infection, while OPPV is typically manifested with labored breathing and emaciation caused by progressive pneumonitis. Most SRLV-infected sheep and goats show no clinical disease but remain persistent carriers of the virus. The major mode of viral transmission is vertically through milk and colostrum. Respiratory secretions and feces also harbor infectious virus. Good management practices, supported by a reliable diagnostic tool, are the best means of controlling the spread of disease.
UBRL Livestock Diagnostics offers a competitive enzyme-linked immunosorbent assay (cELISA) that is licensed to detect antibodies to caprine CAEV in goat sera and antibodies to OPPV in sheep sera. This ELISA test utilizes a proprietary xeno-monoclonal antibody derived by fusion of goat splenocytes and mouse myeloma cells which has excellent characteristics for use in cELISA. This ELISA Kit is USDA approved.